Atlanta study suggests female hormone may be effective treatment for traumatic brain injury
Animal studies have indicated that giving progesterone soon after injury reduces brain swelling, prevents nerve death and improves functional outcomes. Lead researcher Dr. David W. Wright and colleagues note that progesterone's advantages over other potential treatments include its ability to quickly enter the brain, history of safe use, ease of administration, and low cost.
Wright, from Emory University in Atlanta, and colleagues included in their study 100 adults with brain injury who reached the emergency department within 11 hours of injury. Patients were randomly assigned to receive an intravenous dose of progesterone or inactive "placebo".
The death rate in the 30 days after injury was 13 percent in the progesterone group compared with 30 percent in the comparison group. This suggests that progesterone cut the risk of death by 57 percent.
Wright's team was able to contact 92 percent of patients who survived 30 days. There was evidence that progesterone improved the recovery of patients with moderate brain injury. Patients with severe injury seemed to glean no benefit from the hormone.
Dr. Wright says his results are preliminary and broader studies are needed.
